Antiphospholipid syndrome: multiple mechanisms
نویسندگان
چکیده
منابع مشابه
Pathophysiological mechanisms in antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by recurrent thrombosis and fetal loss in the presence of persistently positive antiphospholipid (aPL) antibodies (Abs) including lupus anticoagulant (LAC), IgG/IgM anticardiolipin (aCL) Abs and anti-b2glycoprotein I (b 2 GPI) Abs [1–3]. aPL Abs are a heterogenous group of autoantibodies that react to phospholipids (...
متن کاملMechanisms of thrombosis in the antiphospholipid syndrome
Los pacientes afectos de síndrome antifosfolipídico (SAF) presentan un riesgo aumentado de padecer trombosis venosas y arteriales, pérdidas fetales recurrentes y/o trombocitopenia. Estas manifestacions clínicas se asocian con la presencia de anticuerpos antifosfolipídicos (AAF), entre los que se incluyen los anticuerpos anticardiolipina (aCL) y el anticoagulante lúpico (AL). A pesar de la estre...
متن کاملPathogenic Mechanisms of Thrombosis in Antiphospholipid Syndrome (APS)
The term "antiphospholipid syndrome" (APS) was coined in the early '80s to describe a unique form of acquired autoimmune thrombophilia, with clinical features of recurrent thrombosis and pregnancy morbidity, combined with the presence of antiphospholipid antibodies (aPL). aPL consist a heterogeneous group of autoantibodies, which recognize phospholipid-protein complexes or rather proteins with ...
متن کاملAnticardiolipin syndrome: antiphospholipid syndrome.
North Am 2000;26:215–27. 14 Savill J. Recognition and phagocytosis of cells undergoing apoptosis. Br Med Bull 1997;53:491–508. 15 Elkon KB. Apoptosis in SLE – too little or too much? Review. Clin Exp Rheumatol 1994;12:553–9. 16 Drappa J, Vaishnaw AK, Sullivan KE, Chu JL, Elkon KB. Fas gene-mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmu...
متن کاملNovel Mechanisms Of Trophoblast Responses To Antiphospholipid Antibodies And Therapeutics In Obstetric Antiphospholipid Syndrome
Obstetric antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by circulating antiphospholipid antibodies (aPL) and an increased risk of recurrent pregnancy loss and preeclampsia. Current treatments, such as low molecular weight heparin (LMWH) may maintain pregnancy but do not reduce the risk of these late gestational complications. aPL trigger placental inflammation ...
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ژورنال
عنوان ژورنال: Clinical and Experimental Immunology
سال: 2004
ISSN: 0009-9104,1365-2249
DOI: 10.1111/j.1365-2249.2004.02497.x